The first Bugatti Type 43 was delivered on June 16th of 1927. At the heart of the Type 43 was its 2.3-liter supercharged straight-eight engine. Except for a lower compression ratio, the Type 43's eight-cylinder supercharged engine, in two four-cylinder blocks, was identical to the one placed in the Type 35B racing car. The car's transmission, axles and radiator came from the Type 38. The car's impressive performance was underlined by WF Bradley when, accompanied by Ettore on a drive in the early Type 43, it was reported that with the standard gear ratio it will run up to 112 mph.
The frame of the Type 43 was all-new and was similar in design to the racing type 35b. The Type 43 featured larger brakes and a larger radiator in order to make it more suitable for the road. The Bugatti Type 43A, introduced in 1929, was more luxurious and thus heavier. With its racing car pedigree it was only natural for Bugatti to campaign the Type 43 and 43A in events like the Brooklands handicap races of the 1930s.